Mandisi is Associate Director and co-Music Director of Isango Ensemble and has been with thecompany since 2006.
He has been co-Music Director and arranger / composer for all Isango
Ensemble productions since 2006, including The Magic Flute – Impempe Yomlingo, A Christmas Carol – iKrismas Kherol, Venus and Adonis, The Mysteries – Yiimimangaliso, Aesop’s Fables and The Ragged Trousered Philanthropists – Izigwili Ezidlakazelayo.
Mandisi travelled to New York to work with Graduate Acting students of New York University’s Tisch School of Acting, as they explored relationships between South African and American theatre methods.
In 2012, Mandisi was the musical director and composer for Isango's Venus & Adonis which opened the Globe to Globe season at Shakespeare's Globe in London and subsequently returned to the Globe in May 2013. He arranged and directed the music for the films Unogumbe and Breathe – Umphefumlo.
In 2015 he adapted Bizet’s Carmen and Britten’s A Midsummer Night’s Dream for Isango’s USA Tour.
In 2016 Mandisi composed and conducted the music for A Man of Good Hope which ran at London’s Young Vic and New York’s BAM, Hong Kong Arts Festival, Grand Théâtre de la Ville de Luxembourg, RuhrFestspiele Recklinghausen and Bergen International Festival.